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Get uses, dosage, side effects of Glucovance, glyburide and metformin HCI, medication for type 2 diabetes. More on Glucovance for controlling diabetes symptoms. Glucovance (glyburide and metformin) is used to treat type 2 diabetes (non-insulin dependent). Includes Glucovance side effects, interactions and indications. Compared to the combination of metformin and glibenclamide when provided as separate components, Glucovance ® provides: • Better HbA1c control 4 • Comparable, consistently low risk of hypoglycemia 5 • Improved adherence 4,6 Compared to monotherapy with metformin or glibenclamide, Glucovance ® provides greater reduction of HbA1c by 1.9% and 1.7%, respectively, 7,8 greater reduction of … Overview Glucovance is a prescription drug approved by the Food and Drug Administration (FDA) to help improve blood glucose control in adults with type 2 diabetes. Glucovance is considered an adjunct treatment to diet and exercise. 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