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Glucotrol XL is a sulfonylurea used along with diet and exercise to lower blood sugar in adults with type 2 diabetes mellitus. Yes, glipizide can cause weight gain in some people. This is a known side effect of sulfonylurea medications, the class that glipizide belongs to. glipizide stimulates your pancreas to make more insulin, and insulin helps your body store sugar and fat. Find today's lowest Glucotrol price. Compare coupons, discount cards, savings programs and pharmacy costs side by side, with or without insurance. While Glucotrol requires a prescription, there are over-the-counter (OTC) anti-diabetic drugs available for managing diabetes. These medications can be beneficial for individuals with milder forms of the condition, offering a cost-effective and accessible option for diabetes management. Survey Results on Glucotrol Efficacy Glipizide is a sulfonylurea medication used to treat Type 2 diabetes in adults. 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