DILTIAZEM (dil TYE a zem) treats high blood pressure and prevents chest pain (angina). It works by relaxing the blood vessels, which helps decrease the amount of work your heart has to do. It belongs to a group of medications called calcium channel blockers. DILTIAZEM (dil TYE a zem) treats high blood pressure and prevents chest pain (angina). It works by relaxing blood vessels, which decreases the amount of work the heart has to do. It belongs to a group of medications called calcium channel blockers. Take this medication by mouth. Take it as directed on the prescription label at the same time … Save on Cardizem Sr (diltiazem hcl) prescription medication with Blink Pharmacy. Same pills. Lower prices. No coupon req. Get a diltiazem (generic Cardizem) prescription online with DrHouse. Fast, personalized care to manage high blood pressure or chest pain effectively. 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